KSOM-R supports both mouse and rat preimplantation embryo development in vitro.
Men H, Amos-Landgraf JM, Bryda, EC, Franklin, CL. (2023) Theriogenology 198:69-74.
The Atg16l1 gene: characterization of wild type, knock-in, and knock-out phenotypes in rats. Chesney KL, Men H, Hankins MA, Bryda EC.(2021) Physiol Genomics 53:269-281.
Mutational analyses of novel rat models with targeted modifications in inflammatory bowel disease susceptibility genes. Men H, Hankins MA, Bock AS, Beaton BP, Davis DJ, Chesney KL, Bryda EC.(2021) Mamm Genome.32:173-182.
Media optimization to promote rat embryonic development to the blastocyst stage in vitro. Men H, Stone BJ, Bryda EC. (2020) Theriogenology 151:81-85.
A Non-surgical Embryo Transfer Protocol for Fresh and Cultured Blastocysts in Rats. Stone BJ, Steele KH, Men H, Srodulski SJ, Bryda, EC, Fath-Goodin, A. (2020) J Am Assoc Lab Anim Sci 59:488-495.
Using vaginal impedance measurement to stage estrous in rats given luteinizing hormone releasing hormone (LHRH) agonist. Chesney KL, Chang C, Bryda EC. (2020) J Am Assoc Lab Anim Sci 59:282-287.
A novel conditional ZsGreen-expressing transgenic reporter rat strain for validating Cre recombinase expression. Bryda EC, Men H, Davis DJ, Bock AS, Shaw ML, Chesney KL, Hankins MA. (2019) Scientific Reports 9:13330.
Letter to the editor announcing the availability of RCS and transgenic rats with P23H and S334ter rhodopsin mutations with inherited retinal degenerations. Bryda EC and LaVail M. (2019) Exp Eye Res. 178:176.
Rat Genome and Model Resources. Shimoyama M, Smith JR, Bryda E, Kuramoto T, Saba L, Dwinell M. (2017) ILAR Journal. 58:42–58.
Derivation of transgene-free rat induced pluripotent stem cells approximating the quality of ES cells. Li S, Lan H, Men H, Wu Y, Li N, Capecchi MR, Bryda EC, Wu S. (2017) Stem Cells Translational Medicine 6:340-351.
Efficient Generation of Selection-Gene-Free Rat Knockout Models by Homologous Recombination in ES Cells. Lan H, Li S, Guo Z, Men H, Wu Y, Li N, Bryda EC, Capecchi M, Wu S. (2016) FEBS Letters 590:3416-3424.
Rapid conditional ablation model for hemolytic anemia in the rat. Hanson MM, Liu F, Dai S, Kearns A, Qin X, Bryda EC. (2016) Physiological Genomics 48:626-632.
Fischer-344 Tp53-knockout rats exhibit a high rate of bone and brain neoplasia with frequent metastasis. Hansen SA, Hart ML, Busi S, Parker T, Goerndt A, Jones K, Amos-Landgraf JM, Bryda EC. (2016) Dis Model Mech. 9(10):1139-1146.
Post-thaw ATP supplementation enhances cryoprotective effect of iodixanol in rat spermatozoa. Kim, S, Hooper, S, Agca, C, Agca, Y. (2016) Reprod Biol Endocrinol. 14:5.
Differential Susceptibility to Colorectal Cancer due to Naturally Occurring Gut Microbiota. Ericsson AC, Akter S, Hanson MM, Busi SB, Parker TW, Schehr RJ, Hankins MA, Ahner CE, Davis JW, Franklin CL, Amos-Landgraf JM, Bryda EC. (2015) Oncotarget 6:33689-33704.
Electroejaculation of chimeric rats. McCoy MR, Montonye D, Bryda EC. (2014) Lab Anim (NY) 42:203-5.
Effect of Gsk3 inhibitor CHIR99021 on aneuploidy levels in rat embryonic stem cells. Bock AS, Leigh ND, Bryda EC. (2014) In Vitro Cell Dev Biol Anim.50:572-579.
Derivation of a Germline Competent Transgenic Fischer 344 Embryonic Stem Cell Line. Men, H and Bryda, EC. (2013) PLoS One 8:e56518.
Germline Transmisson of a Novel Rat Embryonic Stem Cell Line Derived from Transgenic rats. Men H. Bauer BA, Bryda EC. (2012) Stem Cells Dev. 21(14):2606-2612.
Changes in rat spermatozoa function after cooling, cryopreservation and centrifugation processes. Kim S, Agca C, Agca Y. (2012) Cryobiology. 65(3):215-223.
Weather and Shipping
The welfare of the animals is of utmost importance and as we head into the summer months, inclement weather and excessive heat will delay/prevent shipments of live animals. Be aware that hot temperatures between June and mid-September may negatively impact the ability of couriers to safely ship animals so please plan your live animal orders accordingly.
Provide Your Input on NIH's Proposed Strategic Plan by May 26, 2026.
The NIH is currently seeking input for its next strategic plan, and a major focus of this framework involves the future of animal research. Because these high-level policies directly impact the future of the RRRC and your work, it’s crucial that the scientific community participates. The NIH has provided a short feedback form that only takes a few minutes to complete. Please consider submitting your input. URL: https://grants.nih.gov/
Animal Models and New Approach Methodologies (NAMs)
NAMs are lab (e.g., organoids and iPSCs) or computer-based methods intended to expand our tools for modeling human biology and disease. While this field is rapidly evolving, the need for animal models remains, especially for situations where a complex biological system is necessary. In addition, animal models serve as vital in vivo controls for the validation and verification of emerging NAMs.