for assistance call: 1-888-673-3444
 
Microbiota Characterization Now Offered
 July 07, 2014
The RRRC now offers a full line of NGS-related services including fecal DNA extraction, 16S rRNA gene sequencing, and informatics analysis to researchers using rat models.  For more information, please see here or contact www.rrrc.us.
Need a New Rat Model?
 March 21, 2017
Need a new rat model?  The RRRC in conjunction with the MU Animal Modeling Core (AMC) can assist with the generation of transgenic rats, create knock-out and knock-in rats using CRISPR/Cas9 technology and genetically manipulate rat embryonic stem cells to make chimeric animals.  Contact us to discuss your rat model needs and how we can help.
RRRC at American Society of Human Genetics
 October 16, 2017
Stop by Booth 949 (Research Resources in Metagenomics and Animal Models) in the Exhibitor Hall at ASHG 2017 in Orlando, FL on Oct 18-20 to discuss how we can help facilitate your research.  
Animal Characterization at Discovery Ridge
 November 06, 2017
Discover what our team is doing related to metagenomics and the animal resource centers at MU including the RRRC, the MU MMRRC, the NSRRC and the MU Animal Modeling Core and the MU Metagenomics Center.
https://vimeo.com/239454305
Rat Genome and Model Resources
 November 10, 2017
Review of available rat resources.  Shimoyama, M, Smith, JR, Bryda, E, Kuramoto, T, Saba, L, Dwinell, M. (2017) Rat Genome and Model Resources. ILAR J 58 (1):42-58.
Precision Mouse Modeling: Translation to Human Disease Symposium
 August 12, 2019
NIDA Center for Genetic Studies of Drug Abuse in Outbred Rats
 August 22, 2019
The NIDA Center for Genetic Studies of Drug Abuse in Outbred Rats (P50DA037844) is calling for applications for Pilot Studies in HS Outbred Rats Supporting Drug Abuse Research.
Remembering Dr. Mary Shimoyama
 March 04, 2020
The faculty and staff of the Rat Genome Database are deeply grieved to announce the recent passing of Dr. Mary Shimoyama, principal investigator of RGD.
COVID-19-related Disruptions
 March 19, 2020

Due to the current situation with COVID-19, we are operating with reduced staffing and there may be delays in responding to emails and phone calls at this time.  In addition, because of institutional restrictions and uncertainty with courier services and transportation, the RRRC is currently shipping and receiving live animals on a case-by-case basis.  For new requests, please contact us to discuss your needs.  For ongoing orders, we will continue to communicate frequently to keep you apprised of the status of your order.  Thank you for understanding.

RRRC Fully Operational
 June 14, 2020
The RRRC is fully operational at this time and we are excited to be able to assist researchers with all their rat-related needs. 
Rats on the rise
 July 20, 2021
Rats on the rise.  Ellen P. Neff (Lab Animal, 2021). After a genetic revolution in the 80s, mice overtook rats as the laboratory animal of choice for many researchers. But in recent years, the gene editing capabilities that had lagged a little for the larger rodent have been coming up to par with their murine cousins. Is a return to rats on the way?
Publications
The Atg16l1 gene: characterization of wild type, knock-in, and knock-out phenotypes in rats. Chesney KL, Men H, Hankins MA, Bryda EC.(2021) Physiol Genomics. 53:269-281.

Mutational analyses of novel rat models with targeted modifications in inflammatory bowel disease susceptibility genes. Men H, Hankins MA, Bock AS, Beaton BP, Davis DJ, Chesney KL, Bryda EC.(2021) Mamm Genome.32:173-182.

Media optimization to promote rat embryonic development to the blastocyst stage in vitro.
Men H, Stone BJ, Bryda EC. (2020) Theriogenology 151:81-85.

A Non-surgical Embryo Transfer Protocol for Fresh and Cultured Blastocysts in Rats. Stone BJ, Steele KH, Men H, Srodulski SJ, Bryda, EC, Fath-Goodin, A. (2020) J Am Assoc Lab Anim Sci 59:488-495.

Using vaginal impedance measurement to stage estrous in rats given luteinizing hormone releasing hormone (LHRH) agonist. Chesney KL, Chang C, Bryda EC. (2020) J Am Assoc Lab Anim Sci 59:282-287.

A novel conditional ZsGreen-expressing transgenic reporter rat strain for validating Cre recombinase expression. Bryda EC, Men H, Davis DJ, Bock AS, Shaw ML, Chesney KL, Hankins MA. (2019) Scientific Reports 9:13330.

Letter to the editor announcing the availability of RCS and transgenic rats with P23H and S334ter rhodopsin mutations with inherited retinal degenerations. Bryda EC and LaVail M. (2019) Exp Eye Res. 178:176.

Rat Genome and Model Resources. Shimoyama M, Smith JR, Bryda E, Kuramoto T, Saba L, Dwinell M. (2017) ILAR Journal. 58:42–58.

Derivation of transgene-free rat induced pluripotent stem cells approximating the quality of ES cells. Li S, Lan H, Men H, Wu Y, Li N, Capecchi MR, Bryda EC, Wu S. (2017) Stem Cells Translational Medicine 6:340-351.

Efficient Generation of Selection-Gene-Free Rat Knockout Models by Homologous Recombination in ES Cells. Lan H, Li S, Guo Z, Men H, Wu Y, Li N, Bryda EC, Capecchi M, Wu S. (2016) FEBS Letters 590:3416-3424.

Rapid conditional ablation model for hemolytic anemia in the rat.
Hanson MM, Liu F, Dai S, Kearns A, Qin X, Bryda EC. (2016) Physiological Genomics 48:626-632.

Fischer-344 Tp53-knockout rats exhibit a high rate of bone and brain neoplasia with frequent metastasis. Hansen SA, Hart ML, Busi S, Parker T, Goerndt A, Jones K, Amos-Landgraf JM, Bryda EC. (2016) Dis Model Mech. 9(10):1139-1146.

Post-thaw ATP supplementation enhances cryoprotective effect of iodixanol in rat spermatozoa. Kim, S, Hooper, S, Agca, C, Agca, Y. (2016) Reprod Biol Endocrinol. 14:5.

Differential Susceptibility to Colorectal Cancer due to Naturally Occurring Gut Microbiota.
Ericsson AC, Akter S, Hanson MM, Busi SB, Parker TW, Schehr RJ, Hankins MA, Ahner CE, Davis JW, Franklin CL, Amos-Landgraf JM, Bryda EC. (2015) Oncotarget 6:33689-33704.

Electroejaculation of chimeric rats. McCoy MR, Montonye D, Bryda EC. (2014) Lab Anim (NY) 42:203-5.

Effect of Gsk3 inhibitor CHIR99021 on aneuploidy levels in rat embryonic stem cells. Bock AS, Leigh ND, Bryda EC. (2014) In Vitro Cell Dev Biol Anim.50:572-579.

Derivation of a Germline Competent Transgenic Fischer 344 Embryonic Stem Cell Line. Men, H and Bryda, EC. (2013) PLoS One 8:e56518.

Germline Transmisson of a Novel Rat Embryonic Stem Cell Line Derived from Transgenic rats. Men H. Bauer BA, Bryda EC. (2012) Stem Cells Dev. 21:2606-2612.

Changes in rat spermatozoa function after cooling, cryopreservation and centrifugation processes. Kim S, Agca C, Agca Y. (2012) Cryobiology.  65:215-223.


Effects of various physical stress factors on mitochondrial function and reactive oxygen species in rat spermatozoa. Kim S, Agca C, Agca Y. (2013) Reprod Fertil Dev. 25:1051-1064.